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Products > Immunoassays > Aquamax -6-keto-prostaglandin F1α Conjugate Product 6-keto-prostaglandin F1α chemically conjugated to Aquamax aequorin.
Application/Background
Prostacyclin, a potent vasodilator with antiplatelet and antiproliferative properties, is an effective treatment for primary pulmonary hypertension and pulmonary arterial hypertension associated with scleroderma and scleroderma-like symptoms. Levels of 6-keto-prostaglandin F1α (6-keto-PGF1α) can be directly correlated with levels of Prostacyclin. Therefore, 6-keto-PGF1a has become the indicator of choice to measure Prostacyclin levels. The Aquamax -6-keto-prostaglandin F1α Conjugate can be used in immunoassays for the measurement of the 6-keto-PGF1α directly in plasma without any pretreatment of the sample resulting in a much simpler method with faster assay time over standard assays (1).
In a solid-phase competitive assay a detection
limit of 1pg/L and a linear dynamic range of 10-1000 nmol/L was
achieved (1). For package size, pricing and availability please contact us. We can customize your order to your requirements.
REFERENCES: 1. Desai, Urvee A. Deo, Sapna K. Hyland, Kenneth V. Poon, Michael. Daunert, Sylvia. Determination of Prostacyclin in Plasma through a Bioluminescent Immunoassay for 6-Keto-prostaglandin F1α: Implication of Dosage in Patients with Primary Pulmonary Hypertension. Anal. Chem. 74, 3892-3898, 2002.
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