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Products > Diagnostics/Immunoassays > Aequroin-Protein C Conjugate

Product

Recombinant Aequorin fused to the HPC4 epitope of Protein C

 

Application/Background 

Protein C is a vitamin K-dependent protein that plays an important role in the maintenance of normal hemostatic mechanisms by down-regulating clot formation and by promoting fibrinolysis. A deficiency in Protein C, which can be either congenital or acquired, may lead to serious thrombotic events such as thrombophlebitis, deep vein thrombosis, or pulmonary embolism.

Homozygous protein C deficiency is associated with fatal neonatal thrombosis and heterozygous protein C deficiency is associated with familial venous thrombosis. In patients affected by protein C deficiency the level of protein C is 40 to 60% of normal. The Aequroin-protein C conjugate can be used in an immunoassay to improve the detection limit of protein C without any loss in selectivity.
 

 

Dose–response curve for protein C obtained by incubating a 100-mL volume of 6.6 x 10-11 M Aequorin-Protein C and varying concentrations of protein C in plasma.   A detection limit 4 x 10-10 M with a dynamic range of 1 x 10-7 M to 1 x 10-7M using plasma was achieved (1).


For package size, pricing and availability please contact us.  We can customize your order to your requirements.

 

 

REFERENCES:

 

1.    Urvee A. Desai, Jennifer A. Winninger, Jennifer C. Lewis, Sridhar Ramanathan, and Sylvia Daunert. “Using 

       Epitope-Aequorin Conjugate Recognition in Immunoassays for Complex Proteins.”  Anal. Biochem. 294, 132-

       140, 2001.

 

 
   

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Last modified: 06/22/2005